
<!DOCTYPE html>
<html lang="zh-CN">
<head>
    <title>dbBIP</title>
    <meta charset="utf-8">
    <link rel="icon" href="http://bioinfo.ahu.edu.cn/dbBIP/image/sourcebicon.png">
    <link href="/css/bootstrap.css" rel="stylesheet">
    <link href="/css/ie10-viewport-bug-workaround.css" rel="stylesheet">
    <link href="/css/navbar-fixed-top.css" rel="stylesheet">
    <link rel="stylesheet" href="/css/jquery-ui.css">
    <link rel="stylesheet" href="/css/bootstrap.min.css">
</head>
<body>
<div class="container">
    
    <div class="panel panel-info logo ">

        <img src="/picture/The_Starry_Night_v2.png" alt="logo" id='logo' align="center" height="100%" width="100%">
    </div>
    <nav class="navbar navbar-default ">
        <div class="navbar-header">
            <button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false" aria-controls="navbar">
                <span class="icon-bar"></span>
                <span class="icon-bar"></span>
                <span class="icon-bar"></span>
            </button>

        </div>
        <div id="navbar" class="navbar-collapse collapse">
            <ul class="nav navbar-nav">
                <li class="dropdown"><a href="../index.html"> Home</a></li>

                <li class="dropdown">
                    <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false">SNP<span class="caret"></span></a>
                    <ul class="dropdown-menu">
                        <li><a href="SNP_PGC2.html"> PGC2 GWAS</a></li>
                        <li><a href="SNP_PGC3.html"> PGC3 GWAS</a></li>
                        <li><a href="Functional_SNPs.html"> Functional SNPs</a></li>
                    </ul>
                </li>
                <li class="dropdown">
                    <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false">Gene<span class="caret"></span></a>
                    <ul class="dropdown-menu">
                        <li><a href="geneList.html">Gene Browser System</a>
                            
                        <li><a href="Gene_PGC3_SMR.html">Genes identified by SMR</a></li>
                        <li><a href="">Genes identified by TWAS</a></li>
                        
                        <li><a href="GeneExpressedDifferentially.html">Genes expressed differentially in PsychENCODE</a>
                        <li><a href="Genes_Identified_by_GWAS.html">Genes Identified by GWAS</a>
                        <li><a href="exonic.html">Genes Identified by exome sequencing</a>
                        <li><a href="CNV.html">Genes Identified by CNVs</a>
                        
                        </li>
                    </ul>
                </li>

                <li class="dropdown">
                    <a href="#" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false">
                        Analysis<span class="caret"></span></a>
                    <ul class="dropdown-menu">
                        <li><a href="LocusZoom.html"> LocusZoom</a></li>
                        <li><a href="AnalysisTranscripteQTL.html">Transcript eQTL query</a></li>
                        <li><a href="AnalysiseQTL.html">Gene eQTL query</a></li>
                        <li><a href="ExpressionPatternAnalysis.html">Expression pattern analysis</a></li>
                        <li><a href="ProteinProteinInteraction.html">Protein-Protein Interaction</a></li>
                        <li><a href="Co-expression.html">Co-expression</a></li>
                        <li><a href="GTEx.html">Tissue expression analysis</a></li>
                    </ul>
                </li>

            </ul>
            <ul class="nav navbar-nav navbar-right">
                <li><a href="Download.html"><span class="glyphicon glyphicon-cloud-download" aria-hidden="true"></span> Download</a>
                </li>
                <li><a href="Manual.html"><span class="glyphicon glyphicon-book" aria-hidden="true"></span> Manual</a></li>
                <li class=""><a href="javascript:;"><span class="glyphicon glyphicon-user" aria-hidden="true"></span> About Us<span class="sr-only">(current)</span></a></li>
            </ul>
        </div>
    </nav>

    <div class="panel panel-default">
        <div class="panel-body  panel-table">
            <h3 align="center">Genes identified by TWAS</h3>
            <hr>

            <div id="tabs">
                <ul>
                    <li><a href="#tabs-1" id="PGC3">PGC3</a></li>
                    <li><a href="#tabs-2" id="PGC2">PGC2</a></li>
                </ul>
                <div id="tabs-1">
                    <form action="/dbBIP/gene_search_TWAS_2" name="association" class="form-inline" id="association" method="post">
                        <div class="col-md-8">
                            <!-- Select method -->
                            <div class="panel panel-primary">
                                <div class="panel-heading">
                                    <h3 class="panel-title">Step1: Select a Brain eQTL dataset</h3>
                                </div>
                                <div class="panel-body">
                                    <input type="radio" name="method" value="PsychENCODE" checked="true">
                                    PsychENCODE
                                </div>
                            </div>
                            <br>
                            <br>
                            <br>
                            <!-- Select  GWAS-->
                            <div class="panel panel-success">
                                <div class="panel-heading">
                                    <h3 class="panel-title">Step2: Input your genes</h3>
                                </div>
                                <div class="panel-body">
                                    <textarea class="form-control" id="gene" maxlength="200" name="gene" rows="5" style="width: 100%;">
</textarea>
                                </div>
                            </div>

                            <!-- Select eQTL -->
                        </div>
                        <div class="col-md-4">
                            <div class="panel panel-default" style="margin-top:3px;">
                                <div class="panel-heading"><span class="glyphicon glyphicon-hand-right" aria-hidden="true"></span> Example for eQTL dataset
                                </div>
                                <div class="panel-body">
                                    eQTLGen<br>
                                </div>
                            </div>
                            <br>
                            <br>
                            <br>
                            <div class="panel panel-default">
                                <div class="panel-heading"><a href="#" style="cursor:hand"><span class="glyphicon glyphicon-hand-right" aria-hidden="true"></span> Example for genes</a></div>
                                <div class="panel-body">
                                     GNL3<br>
                                    ADD3<br>
                                    TMEM258<br>


                                </div>
                            </div>
                        </div>
                        <div class="col-md-12">
                            <div class="sub_button">
                                <button type="submit" class="btn btn-success" value="Search">Search</button>
                                <button type="reset" class="btn btn-info" value="Reset">Reset</button>
                            </div>
                        </div>
                    </form>
                </div>
                <div id="tabs-2">
                    <form action="/dbBIP/Gene_TWAS/search" method="post" class="form-inline" role="form">
                        <div class="col-md-8">
                            <!-- Select method -->
                            <div class="panel panel-primary">
                                <div class="panel-heading">
                                    <h3 class="panel-title">Step1: Select a Brain eQTL dataset</h3>
                                </div>
                                <div class="panel-body">
                                    <input type="radio" name="eQTL_dataset" value="CMC" id="smr" checked="true">CMC&nbsp;&nbsp;&nbsp;&nbsp;
                                    <input type="radio" name="eQTL_dataset" value="LIBD2-DLPFC" id="sherlock">
                                    LIBD2-DLPFC
                                    <input type="radio" name="eQTL_dataset" value="PsychEncode" id="PsychEncode ">
                                    PsychEncode 
                                </div>
                            </div>
                            <br> <br> <br>
                            <!-- Select  GWAS-->
                            <div class="panel panel-success">
                                <div class="panel-heading">
                                    <h3 class="panel-title">Step2: Input your genes</h3>
                                </div>
                                <div class="panel-body">
                                    <textarea class="form-control" id="gene" maxlength="200" name="gene" rows="5" style="width: 100%;">
</textarea>
                                </div>
                            </div>
                            <!-- Select eQTL -->
                        </div>
                        <!-- example -->
                        <div class="col-md-4">
                            <div class="panel panel-default">
                                <div class="panel-heading"><span class="glyphicon glyphicon-hand-right" aria-hidden="true"></span> Example for eQTL dataset
                                </div>
                                <div class="panel-body">
                                    CMC <br>
                                </div>
                            </div>
                            <br>
                            <br><br>
                            <div class="panel panel-default">
                                <div class="panel-heading"><a href="#" style="cursor:hand"><span class="glyphicon glyphicon-hand-right" aria-hidden="true"></span> Example for
                                    genes</a>
                                </div>
                                <div class="panel-body">
                                    CDHR1<br>
                                    CSPG4P12<br>
                                    FADS1<br>
                                    MED24<br>
                                </div>
                            </div>
                        </div>
                        <div class="col-md-12">
                            <div class="sub_button">
                                <button type="submit" class="btn btn-success" value="Search">Search</button>
                                <button type="reset" class="btn btn-info" value="Reset">Reset</button>
                            </div>
                        </div>
                    </form>
                </div>

            </div>


            <div class="col-md-12 panel-note">
                <div class="panel panel-warning">
                    <div class="panel-heading">
                        <h3 class="panel-title"><span class="glyphicon glyphicon-bookmark" aria-hidden="true"></span>
                            References</h3>
                    </div>
                    <div class="panel-body">
                        <table class="note-table">
                            <tr>
                                <td class="note-1td">TWAS</td>
                                <td>- Integrative approaches for large-scale transcriptome-wide association studies.
                                    Nature Genetics, 48(3):245-52. [<a href='javascript:;' target='_blank'>PMID: 26854917</a>]
                                </td>
                            </tr>
                            <tr>
                                <td class="note-1td">PGC3 GWAS</td>
                                <td>- Genome-wide association study of more than 40,000 bipolar disorder cases provides
                                    new insights into the underlying biology. Nature Genetics, 53(6):817-829. [<a href='javascript:;' target='_blank'>PMID: 34002096</a>]
                                </td>
                            </tr>
                            <tr>
                                <td class="note-1td">PGC2 GWAS</td>
                                <td> - Biological insights from 108 schizophrenia-associated genetic loci. Nature,
                                    511(7510):421-427. [<a href='javascript:;' target='_blank'>PMID: 31043756</a>]
                                </td>
                            </tr>
                            <tr>
                                <td class="note-1td">CMC eQTL</td>
                                <td> - Gene expression elucidates functional impact of polygenic risk for schizophrenia.
                                    Nature Neuroscience, 19(11):1442-1453. [ <a href='javascript:;' target='_blank'>PMID: 27668389</a>]
                                </td>
                            </tr>
                            <tr>
                                <td class="note-1td">LIBD2-DLPFC eQTL</td>
                                <td> - Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the
                                    Frontal Cortex and Hippocampus across Development and Schizophrenia.
                                    Neuron,103(2):203-216.e8. [<a href='javascript:;' target='_blank'>PMID: 31174959</a>]
                                </td>
                            </tr>
                            <tr>
                                <td class="note-1td">PsychEncode eQTL</td>
                                <td> - Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar
                                    disorder. Science, 362(6420):eaat8127. [<a href='javascript:;' target='_blank'>PMID: 30545856</a>])
                                </td>
                            </tr>
                        </table>
                        <span style="font-size:16px;"><b>If you used the integrative analysis result in this database, please cite the relative references.</b></span>
                    </div>
                </div>
            </div>
        </div>
    </div>
</div>

    <div class="container">
    <div class="footer">

        <div class="copyright">
            Copyright©
            <a class="ow" href="../index1.html" target="_blank">AnHui University</a> ©All Rights
            Reserved.
        </div>
        <div>
            <a class="ow" href="javascript:;" target="_blank">皖ICP备20012750号-1</a>
        </div>
    </div>


<!-- Bootstrap core JavaScript
================================================== -->
<!-- Placed at the end of the document so the pages load faster -->
<script src="/js/jquery-2.1.3.min.js"></script>
<script>window.jQuery || document.write('<script src="..//assets/js/vendor/jquery.min.js"><\/script>')</script>
<script src="/js/bootstrap.min.js"></script>
<script src="/js/ie10-viewport-bug-workaround.js"></script>
<script src="/js/jquery-ui.js"></script>
<script language="javascript" type="text/javascript">
    $(function () {
        $("#tabs").tabs();

        var $panel_snp_height = $('div#tabs-1 div.panel-primary').height();
        $('div#tabs-1 div.panel-default:eq(0)').css("height", $panel_snp_height);

        var $panel_gene_height = $('div#tabs-1 div.panel-success').height() + 1;
        $('div#tabs-1 div.panel-default:eq(1)').css("height", $panel_gene_height);

        var $panel_region_height = $('div#tabs-1 div.panel-info').height() + 3;
        $('div#tabs-1 div.panel-default:eq(2)').css("height", $panel_region_height);

        var $div1_height = $('div#tabs-1 div.col-md-8').height() - 10;
        $('div#tabs-1').css("height", $div1_height);

        //var $panel_snp_height2 = $('div.panel-primary:eq(1)').height();
        $('div#tabs-2 div.panel-default:eq(0)').css("height", 94.8);

        //var $panel_gene_height2 = $('div#tabs-2 div.panel-success').height() + 1;
        $('div#tabs-2 div.panel-default:eq(1)').css("height", 180);

        //var $panel_region_height2 = $('div#tabs-2 div.panel-info').height() + 3;
        $('div#tabs-2 div.panel-default:eq(2)').css("height", 143.8);

        //var $div2_height = $('div#tabs-2 div.col-md-8').height();
        $('div#tabs-2').css("height", 382.8);

        $(document).click(function () {
            if ($("input[name=method][value=SMR]").prop("checked")) {
                $("td[id=eMyers]").hide();
            } else {
                $("td[id=eMyers]").show();
            }
            if ($("input[name=method][value=Sherlock]").prop("checked")) {
                $("td[class=smr]").hide();
            } else {
                $("td[class=smr]").show();
            }
            var $panel_region_height = $('div#tabs-1 div.panel-info').height() + 3;
            $('div#tabs-1 div.panel-default:eq(2)').css("height", $panel_region_height);

            var $div1_height = $('div#tabs-1 div.col-md-8').height() - 10;
            $('div#tabs-1').css("height", $div1_height);
        })

        $('a#meQTL').click(function () {
            $('input#sherlock').prop("disabled", true);
            $('input#smr').prop("checked", true);
        })

        $('div.panel-heading a:eq(0)').click(function () {
            $('textarea.form-control:eq(0)').val("GNL3\nADD3\nTMEM258");
        })
        $('div.panel-heading a:eq(1)').click(function () {
            $('textarea.form-control:eq(1)').val("CDHR1\nCSPG4P12\nFADS1\nMED24");
        })


    })
</script>
</div></body>
</html>